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8. EFFECT OF PCDDs ON HUMAN BEINGS - EPIDEMIOLOGICAL AND CASE STUDIES
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EXTRACTS EHC88
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8.5 Human Experimental Studies
Poiger & Schlatter (1986) studied a human volunteer after ingestion of a single dose of 1.14 µg 3H-TCDD/kg body weight. The absorption from the intestine was > 87% and adipose tissue levels were 3.09 (± 0.05) and 2.85 (± 0.28) ng/kg after 13 and 69 days, respectively. The estimated half-life of TCDD was 2120 days. Gorski et al. (1984) calculated the half-lives of 1,2,3,6,7,8-hexaCDD, 1,2,3,4,6,7,8-heptaCDD and octaCDF to be about 3.5, 3.6 and 2 years, respectively.
The estimation was based on the analysis of fat tissue biopsies collected with an interval of 28 months from one 14-year-old girl who for a period of about 2-3 years had been exposed to technical pentachlorophenol. Analysis was performed by gas chromatography with electron capture detection, and the isomers were confirmed by the use of several different packed and capillary columns.
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